The formation of continental crust in the Mongolia-Transbaikalia region is researched to identify the mechanisms of interactions between the crust and the mantle in the development of the Neoarchean, Proterozoic and Paleozoic magmatic and sedimentary complexes in the study area.Using the results of his own studies conducted for many years and other
Increasing efficiency of preclinical research by group sequential designs.
Despite the potential benefits of sequential designs, studies evaluating treatments or experimental manipulations in preclinical experimental biomedicine almost exclusively use classical block designs.Our aim with this article is to bring the existing methodology of group sequential designs to the attention of researchers in the preclinical field l
Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis
Glucocorticoids are widely used as an ophthalmic medication.A common, sight-threatening adverse event of glucocorticoid usage is ocular hypertension, caused by dysfunction of the conventional outflow pathway.We report that netarsudil, a rho-kinase inhibitor, decreased glucocorticoid-induced ocular hypertension in patients whose intraocular pressure
An evaluation of a SVA retrotransposon in the FUS promoter as a transcriptional regulator and its association to ALS.
Genetic mutations of FUS have been linked to many diseases including Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration.A Hockey Skates - Junior - Performance primate specific and polymorphic retrotransposon of the SINE-VNTR-Alu (SVA) family is present upstream of the FUS gene.Here we have demonstrated that this retrotranspos
Entropy Analysis of Heart Rate Variability in Different Sleep Stages
How the complexity or irregularity of heart rate variability (HRV) changes across different sleep stages and the importance of these features in sleep staging are not fully understood.This study aimed to investigate the complexity or irregularity of the RR interval time series in different sleep stages and explore Face Mirrors their values in sleep